Kolb Lab Emmy Noether DFG

The Kolb Lab is located at the Department of Pharmaceutical Chemistry at Philipps-Universität Marburg.
The lab is deeply involved in COST Action CM1207 "GLISTEN: GPCR-Ligand Interactions, Structures, and Transmembrane Signalling: a European Research Network".
We are also a member lab of SYNMIKRO
and SynChemBio.

Research interests

Word cloud generated with Wordle from publication abstracts. Thanks to Xavier Deupi for the idea!

Small molecules are frequently used both in Nature and therapeutically to modulate the activity of the protein they bind to. Yet, many aspects of small-molecule:protein interactions are surprisingly poorly understood. For instance, ligand polypharmacology, i.e. binding to multiple proteins, often comes as a surprise, although it is frequently precisely the reason for a drug's efficacy or its side effects. On the protein side, a point mutation in the binding site, although only a small change, can abolish drug binding, leading to resistance. Thus, it is highly relevant to develop a comprehensive understanding of small-molecule:protein interaction profiles in molecular detail and correlate these profiles with signaling and metabolic pathways.

Our main tool is small molecule docking, but we also use chemoinformatic approaches and molecular dynamics. The research spans method development, basic research and applications. Currently the investigations deal with kinases and G-protein coupled receptors (GPCRs).


Most recent:
23 Tryptophan C5-, C6- and C7-Prenylating Enzymes Displaying a Preference for C-6 of the Indole Ring in the Presence of Unnatural Dimethylallyl Diphosphate Analogues
Julia Winkelblech, Mike Liebhold, Jakub Gunera, Xiulan Xie, Peter Kolb, Shu-Ming Li
Adv. Synth. Catal. 2015, 357, 975-986. [pdf]
22 Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant
Jie Yin, Juan Carlos Mobarec, Peter Kolb, Daniel M. Rosenbaum
Nature 2015, 519, 247-250. [pdf] [press release] [news item @ derstandard.at]
21 Identifying Modulators of CXC Receptors 3 and 4 with Tailored Selectivity using Multi-Target Docking
Denis Schmidt, Viachaslau Bernat, Regine Brox, Nuska Tschammer*, Peter Kolb*
ACS Chem. Biol. 2015, 10, 715-724. [pdf]
full list

Lab members

Lab Mar 2015
Clarissa Springer [Intern]
Juan Carlos Mobarec [Postdoc]
Steffen Hartmann [Intern]
Florent Chevillard [Graduate Student]
Matthäus Drabek [Intern]
Corey Taylor [Graduate Student]
Peter Kolb [Principal Investigator]
Anja Witzenhausen [Graduate Student]
Denis Schmidt [Graduate Student]
Jakub Gunera [Graduate Student]
Not in picture:
Christine Berger [Assistant]


Daim – a program to generate fragments


Joining the Lab

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