kolblab.org

Kolb Lab Emmy Noether DFG

The Kolb Lab is located at the Department of Pharmaceutical Chemistry at Philipps-Universität Marburg.
The lab is deeply involved in COST Action CM1207 "GLISTEN: GPCR-Ligand Interactions, Structures, and Transmembrane Signalling: a European Research Network".
We are also a member lab of SYNMIKRO
and SynChemBio.
[en][de]


Research interests

Docking
Word cloud generated with Wordle from publication abstracts. Thanks to Xavier Deupi for the idea!

Small molecules are frequently used both in Nature and therapeutically to modulate the activity of the protein they bind to. Yet, many aspects of small-molecule:protein interactions are surprisingly poorly understood. For instance, ligand polypharmacology, i.e. binding to multiple proteins, often comes as a surprise, although it is frequently precisely the reason for a drug's efficacy or its side effects. On the protein side, a point mutation in the binding site, although only a small change, can abolish drug binding, leading to resistance. Thus, it is highly relevant to develop a comprehensive understanding of small-molecule:protein interaction profiles in molecular detail and correlate these profiles with signaling and metabolic pathways.

Our main tool is small molecule docking, but we also use chemoinformatic approaches and molecular dynamics. The research spans method development, basic research and applications. Currently the investigations deal with kinases and G-protein coupled receptors (GPCRs).


Publications

Most recent:
20 Functional Annotation and Structural Characterization of a Novel Lactonase Hydrolyzing D-Xylono-1,4-lactone-5-phosphate and L-Arabino-1,4-lactone-5-phosphate
Magdalena Korczynska, Dao Feng Xiang, Zhening Zhang, Chengfu Xu, Tamari Narindoshvili, Siddhesh Kamat, Howard J. Williams, Shawn S. Chang, Peter Kolb, Brandan S. Hillerich, J. Michael Sauder, Stephen K. Burley, Steven C. Almo, Subramanyam Swaminathan, Brian K. Shoichet, and Frank M. Raushel
Biochemistry 2014, 53, 4727-4738 [pdf]
full list

Lab members

Lab Apr 2014
Juan Carlos Mobarec [Postdoc]
Chelsey Collins [Intern]
Christina Behrens [former Intern]
Steffen Hartmann [Intern]
Jakub Gunera [Graduate Student]
Christine Berger [Assistant]
Florent Chevillard [Graduate Student]
Denis Schmidt [Graduate Student]
Peter Kolb [Principal Investigator]

Teaching


Daim – a program to generate fragments


Joining the Lab




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